Article

SIRT2 protects against Japanese encephalitis virus infection in mice

2025-03-25

Abstract excerpt

Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic RNA virus that causes Japanese encephalitis (JE) and poses a major threat to public health in Southeast Asia and the Western Pacific. Current strategies rely on prophylactic methods to prevent disease, as no effective antiviral therapy exists. Here, we report that SIRT2, an NAD+-dependent deacetylase enzyme, mediates antiviral activity against JEV infe...

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Identifiers and source

Literature Corpus work: b087c43a-013e-5d05-a513-1759c928761f
DOI: 10.1101/2025.03.24.645101

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