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Regulatory Dynamics of Nrf2 With Sirtuins in the Brain: Exploring Cellular Metabolism, Synaptic Plasticity, and Defense Mechanisms

29 Aug 2025

Abstract excerpt

ABSTRACT Nuclear factor erythroid 2–related factor 2 (Nrf2) plays a pivotal role as a transcription factor at the heart of cellular defense mechanisms against oxidative stress, orchestrating a suite of cytoprotective genes. This review places particular emphasis on the interplay between Nrf2 and Sirtuins—NAD + ‐dependent deacetylases integral to redox regulation, metabolic control, and neuroprotection. We...

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PMID: 40878635
DOI: 10.1111/jnc.70193

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