Article

Tissue-specific MicroRNA Expression Alters Cancer Susceptibility Conferred by a <i>TP53</i> Noncoding Variant

2019-03-20

Abstract excerpt

<h4>ABSTRACT</h4> Patients carrying TP53 germline mutations develop Li-Fraumeni syndrome (LFS), a rare genetic disorder with high risk of several cancers, most notably breast cancer, sarcoma, and brain tumors. A noncoding polymorphism (rs78378222) in TP53 , carried by scores of millions of people, was associated with moderate risk of brain, colon, and prostate tumors, and other neoplasms. We found a positive as...

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Literature Corpus work: da34e683-36d8-5395-bcd7-81b96bfad82f
DOI: 10.1101/582478

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