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Article

Genetic modeling of Li-Fraumeni syndrome in zebrafish.

Disease models & mechanisms - 1 Jan 2000

Parant John M, George Stephen A, Holden Joseph A, Yost H Joseph

Abstract excerpt

Li-Fraumeni syndrome (LFS) is a highly penetrant, autosomal dominant, human familial cancer predisposition. Although a key role for the tumor suppressor p53 has been implicated in LFS, the genetic and cellular mechanisms underpinning this disease remain unknown. Therefore, modeling LFS in a vertebrate system that is accessible to both large-scale genetic screens and in vivo cell biological studies will facilitate...

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Source

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Identifiers

PMID: 20075382
DOI: 10.1242/dmm.003749
PMCID: PMC2806900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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