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A syngeneic spontaneous zebrafish model of <i>tp53</i> -deficient, EGFR <sup>vIII</sup> , and PI3KCA <sup>H1047R</sup> -driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse <i>in vivo</i>

2023-10-20

Abstract excerpt

High-throughput vertebrate animal model systems for the study of patient-specific biology and new therapeutic approaches for aggressive brain tumors are currently lacking, and new approaches are urgently needed. Therefore, to build a patient-relevant in vivo model of human glioblastoma, we expressed common oncogenic variants including activated human EGFR vIII and PI3KCA H1047R under the control of the radial g...

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Literature Corpus work
59fa41de-5a5f-521c-95d0-25347f352660
DOI
10.1101/2023.10.17.562653
Open publication

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A syngeneic spontaneous zebrafish model of <i>tp53</i> -deficient, EGFR <sup>vIII</sup> , and PI3KCA <sup>H1047R</sup> -driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse <i>in vivo</i>DOI 10.1101/2023.10.17.562653
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