Article
Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations.
Nature communications - 18 Jan 2017
Li Yvonne Y, Chung Grace T Y, Lui Vivian W Y, To Ka-Fai, Ma Brigette B Y, Chow Chit, Woo John K S, Yip Kevin Y, Seo Jeongsun, Hui Edwin P, Mak Michael K F, Rusan Maria, Chau Nicole G, Or Yvonne Y Y, Law Marcus H N, Law Peggy P Y, Liu Zoey W Y, Ngan Hoi-Lam, Hau Pok-Man, Verhoeft Krista R, Poon Peony H Y, Yoo Seong-Keun, Shin Jong-Yeon, Lee Sau-Dan, Lun Samantha W M, Jia Lin, Chan Anthony W H, Chan Jason Y K, Lai Paul B S, Fung Choi-Yi, Hung Suet-Ting, Wang Lin, Chang Ann Margaret V, Chiosea Simion I, Hedberg Matthew L, Tsao Sai-Wah, van Hasselt Andrew C, Chan Anthony T C, Grandis Jennifer R, Hammerman Peter S, Lo Kwok-Wai
Abstract excerpt
Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC genomic data hinders the understanding of NPC biology, disease progression and rational therapy design. Here we performed whole-exome sequencing (WES) on 111 micro-dissected EBV-positive NPCs, with 15 cases subjected to further whole-genome...
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