Article
Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication.
EBioMedicine - 1 Oct 2022
Xiao Ruo-Wen, Wang Fang, Wang Tong-Min, Zhang Jiang-Bo, Wu Zi-Yi, Deng Chang-Mi, Liao Ying, Zhou Ting, Yang Da-Wei, Dong Si-Qi, Xue Wen-Qiong, He Yong-Qiao, Zheng Xiao-Hui, Li Xi-Zhao, Zhang Pei-Fen, Zhang Shao-Dan, Hu Ye-Zhu, Liu Yu-Ying, Xia Yun-Fei, Gao Song, Mu Jian-Bing, Feng Lin, Jia Wei-Hua
Abstract excerpt
BACKGROUND: Nasopharyngeal carcinoma (NPC) exhibits significant familial aggregation; however, its susceptibility genes are largely unknown. Thus, this study aimed to identify germline mutations that might contribute to the risk of familial NPC, and explore their biological functions. METHODS: Whole-exome sequencing was performed in 13 NPC pedigrees with multiple cases. Mutations co-segregated with disease status...
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