Article
The genomic landscape of nasopharyngeal carcinoma.
Nature genetics - 1 Aug 2014
Lin De-Chen, Meng Xuan, Hazawa Masaharu, Nagata Yasunobu, Varela Ana Maria, Xu Liang, Sato Yusuke, Liu Li-Zhen, Ding Ling-Wen, Sharma Arjun, Goh Boon Cher, Lee Soo Chin, Petersson Bengt Fredrik, Yu Feng Gang, Macary Paul, Oo Min Zin, Ha Chan Soh, Yang Henry, Ogawa Seishi, Loh Kwok Seng, Koeffler H Phillip
Abstract excerpt
Nasopharyngeal carcinoma (NPC) has extremely skewed ethnic and geographic distributions, is poorly understood at the genetic level and is in need of effective therapeutic approaches. Here we determined the mutational landscape of 128 cases with NPC using whole-exome and targeted deep sequencing, as well as SNP array analysis. These approaches revealed a distinct mutational signature and nine significantly mutated...
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