Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.

doi:10.1038/s41586-021-03237-4

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Article

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.

Nature - 1 Mar 2021

Johnson Bryan A, Xie Xuping, Bailey Adam L, Kalveram Birte, Lokugamage Kumari G, Muruato Antonio, Zou Jing, Zhang Xianwen, Juelich Terry, Smith Jennifer K, Zhang Lihong, Bopp Nathen, Schindewolf Craig, Vu Michelle, Vanderheiden Abigail, Winkler Emma S, Swetnam Daniele, Plante Jessica A, Aguilar Patricia, Plante Kenneth S, Popov Vsevolod, Lee Benhur, Weaver Scott C, Suthar Mehul S, Routh Andrew L, Ren Ping, Ku Zhiqiang, An Zhiqiang, Debbink Kari, Diamond Michael S, Shi Pei-Yong, Freiberg Alexander N, Menachery Vineet D

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-a new coronavirus that has led to a worldwide pandemic1-has a furin cleavage site (PRRAR) in its spike protein that is absent in other group-2B coronaviruses2. To explore whether the furin cleavage site contributes to infection and pathogenesis in this virus, we generated a mutant SARS-CoV-2 that lacks the furin cleavage site (ΔPRRA). Here we report...

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PMID: 33494095
DOI: 10.1038/s41586-021-03237-4
PMCID: PMC8175039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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