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Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2

23 Jun 2020

Abstract excerpt

The spike protein determines the infectivity and host range of coronaviruses. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has two unique features in its spike protein, the receptor binding domain and an insertion of 12 nucleotides at the S1/S2 boundary resulting in a furin-like cleavage site. Here, we identified two deletion variants of SARS-CoV-2 that either directly affect the furin-like...

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PMID: 32571797
DOI: 10.1128/jvi.00790-20

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Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2PMID 32571797Read ↗

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