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Article

Assessing the mechanism of fast-cycling cancer-associated mutations of Rac1 small Rho GTPase.

Protein science : a publication of the Protein Society - 1 Apr 2024

Parise Angela, Magistrato Alessandra

Abstract excerpt

Rho-GTPases proteins function as molecular switches alternating from an active to an inactive state upon Guanosine triphosphate (GTP) binding and hydrolysis to Guanosine diphosphate (GDP). Among them, Rac subfamily regulates cell dynamics, being overexpressed in distinct cancer types. Notably, these proteins are object of frequent cancer-associated mutations at Pro29 (P29S, P29L, and P29Q). To assess the impact...

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Identifiers

PMID: 38501467
DOI: 10.1002/pro.4939
PMCID: PMC10949326

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