Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases.

doi:10.1016/s0092-8674(03)00315-5

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Article

Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases.

Cell - 2 May 2003

Heo Won Do, Meyer Tobias

Abstract excerpt

Signaling proteins from the same family can have markedly different roles in a given cellular context. Here, we show that expression of one hundred constitutively active human small GTPases induced cell morphologies that fell into nine distinct classes. We developed an algorithm for pairs of classes that predicted amino acid positions that can be exchanged to create mutants with switched functionality. The...

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PMID: 12732140
DOI: 10.1016/s0092-8674(03)00315-5

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CDC42

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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