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Article

Activation Mechanism of RhoA Caused by Constitutively Activating Mutations G14V and Q63L.

International journal of molecular sciences - 7 Dec 2022

Chen Shiyao, Zhang Zirui, Zhang Yijing, Choi Taeyoung, Zhao Yaxue

Abstract excerpt

RhoA, a member of Rho GTPases, regulates myriad cellular processes. Abnormal expression of RhoA has been implicated in various diseases, including cancers, developmental disorders and bacterial infections. RhoA mutations G14V and Q63L have been reported to constitutively activate RhoA. To figure out the mechanisms, in total, 1.8 μs molecular dynamics (MD) simulations were performed here on RhoAWT and mutants G14V...

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Identifiers

PMID: 36555100
DOI: 10.3390/ijms232415458
PMCID: PMC9778661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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