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Article

How Functional Variants Reconfigure the Rac2 Conformational Landscape.

The journal of physical chemistry. B - 13 Aug 2026

Haspel Nurit, Jang Hyunbum, Nussinov Ruth

Abstract excerpt

Rac2, a member of the Rho family of small GTPases, is a fundamental regulator of essential cellular processes. Pathogenic substitutions near and within the Switch II region, specifically D57N and E62K, have been implicated in oncogenesis and immunodeficiency. Despite their proximity, D57N is characterized as a loss-of-function mutation, while E62K is a constitutively active, gain-of-function mutation. In this...

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Identifiers

PMID: 42593131
DOI: 10.1021/acs.jpcb.6c02540
PMCID: PMC13479605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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