Article

Development of a Notch pathway assay and quantification of functional Notch pathway activity in T-cell acute lymphoblastic leukemia

2020-07-11

Abstract excerpt

The Notch signal transduction pathway is pivotal for various physiological processes including immune responses, and has been implicated in the pathogenesis of many diseases including T-cell acute lymphoblastic leukemia. Various targeted drugs are available that inhibit Notch pathway signaling, but their effectiveness varies due to variable Notch pathway activity among individual patients. Quantitative measurement...

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Literature Corpus work: 68bb408f-27f2-59cb-948b-1d9f69cc601a
DOI: 10.1101/2020.07.10.183731

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