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Article

The NOTCH Pathway and Its Mutations in Mature B Cell Malignancies

26 Nov 2018

Abstract excerpt

The systematic application of next-generation sequencing to large cohorts of oncologic samples has opened a Pandora’s box full of known and novel genetic lesions implicated in different steps of cancer development and progression. Narrowing down to B cell malignancies, many previously unrecognized genes emerged as recurrently mutated. The challenge now is to determine how the mutation in a given gene affects the...

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PMID: 30534535
DOI: 10.3389/fonc.2018.00550

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