Article
Linking changes in epithelial morphogenesis to cancer mutations using computational modeling.
PLoS computational biology - 26 Aug 2010
Rejniak Katarzyna A, Wang Shizhen E, Bryce Nicole S, Chang Hang, Parvin Bahram, Jourquin Jerome, Estrada Lourdes, Gray Joe W, Arteaga Carlos L, Weaver Alissa M, Quaranta Vito, Anderson Alexander R A
Abstract excerpt
Most tumors arise from epithelial tissues, such as mammary glands and lobules, and their initiation is associated with the disruption of a finely defined epithelial architecture. Progression from intraductal to invasive tumors is related to genetic mutations that occur at a subcellular level but manifest themselves as functional and morphological changes at the cellular and tissue scales, respectively. Elevated...
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