Article

Human Endogenous Retrovirus as Therapeutic Targets in Neurologic Disease

2021-04-09

Abstract excerpt

Human endogenous retroviruses (HERVs) are ancient retroviral DNA sequences established into germline. They contain regulatory elements and encoded proteins few of which may provide benefits to hosts when co-opted as cellular genes. Their tight regulation is mainly achieved by epigenetic mechanisms which can be altered by environmental factors, e.g. viral infections, leading to HERV activation. Aberrant expression...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68b1dbdf-e42f-5bbb-bce0-0bbc0007b31b
DOI: 10.20944/preprints202104.0262.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Endogenous Retrovirus as Therapeutic Targets in Neurologic DiseaseDOI 10.20944/preprints202104.0262.v1Read

Interplay between activation of endogenous retroviruses and inflammation as common pathogenic mechanism in neurological and psychiatric disordersSemantic proximity Read

Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune ResponsesSemantic proximity Read

Do Human Endogenous Retroviruses Contribute to Multiple Sclerosis, and if So, How?Semantic proximity Read

Endogenous Retroviruses in Nervous System DisordersSemantic proximity Read

Viruses and Endogenous Retroviruses as Roots for Neuroinflammation and Neurodegenerative DiseasesSemantic proximity Read

Endogenous retrovirus activation: potential for immunology and clinical applicationsSemantic proximity Read

HSV-1 and Endogenous Retroviruses as Risk Factors in DemyelinationSemantic proximity Read

Human endogenous retroviruses and cancer: causality and therapeutic possibilities.Semantic proximity Read

Endogenous Retroviruses as Modulators of Innate ImmunitySemantic proximity Read

Diseases of the nERVous system: retrotransposon activity in neurodegenerative diseaseSemantic proximity Read

HERV Dysregulation in a Case of Myalgic Encephalomyelitis and Multiple Sclerosis Responsive to RituximabSemantic proximity Read

Endogenous retroviruses in multiple sclerosis: A network-based etiopathogenic modelSemantic proximity Read