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Do Human Endogenous Retroviruses Contribute to Multiple Sclerosis, and if So, How?

25 Jul 2018

Abstract excerpt

The gammaretroviral human endogenous retrovirus (HERV) families MRSV/HERV-W and HERV-H (including the closely related HERV-Fc1) are associated with an increased risk of multiple sclerosis (MS). Complete HERV sequences betray their endogenous retroviral origin, with open reading frames in gag, pro, pol and env being flanked by two long terminal repeats containing promoter and enhancer sequences with the capacity...

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PMID: 30047100
DOI: 10.1007/s12035-018-1255-x

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