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Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune Responses

10 Sept 2018

Abstract excerpt

About 8% of our genome is composed of sequences with viral origin, namely human Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the primates' germ line along the last 100 million of years, and became stable elements at the interface between self and foreign DNA. Intriguingly, HERV co-evolution with the host led to the domestication of activities previously devoted to the...

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PMID: 30250470
DOI: 10.3389/fimmu.2018.02039

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