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Article

Human endogenous retroviruses and cancer: causality and therapeutic possibilities.

World journal of gastroenterology - 14 Nov 2012

Mullins Christina S, Linnebacher Michael

Abstract excerpt

A substantial part of the human genome is derived from transposable elements; remnants of ancient retroviral infections. Conservative estimates set the percentage of human endogenous retroviruses (HERVs) in the genome at 8%. For the most part, the interplay between mutations, epigenetic mechanisms and posttranscriptional regulations silence HERVs in somatic cells. We first highlight mechanisms by which activation...

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Identifiers

PMID: 23155332
DOI: 10.3748/wjg.v18.i42.6027
PMCID: PMC3496880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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