Article

Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers

2023-11-02

Abstract excerpt

<title>Abstract</title> Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produce durable treatment responses. Here, we developed multiple models of acquired resistance to dual-mechanism ERK/MAPK inhibitors across KRAS-mutant pa...

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Literature Corpus work: 87b0f066-d04b-5a8a-9114-db098d7072f9
DOI: 10.21203/rs.3.rs-3511242/v1

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