Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prospects for understanding and exploiting the consequences of hyperactivation lethality

19 May 2025

Abstract excerpt

Cancer cells optimize oncogenic signaling to maintain a defined range for survival. The success of targeted therapeutic inhibitors is based on suppressing signaling below this optimal fitness zone. Conversely, cancers are also susceptible to a clinically underutilized vulnerability - oncogenic hyperactivation. Cytotoxic hyperactivation is observed across diverse cancers, with direct small-molecule activators and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical effects in animals
Share to Eicosanoids and Hypertension Pharmacology
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40393917
DOI: 10.1016/j.trecan.2025.04.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prospects for understanding and exploiting the consequences of hyperactivation lethalityPMID 40393917Read ↗

Hyperactivation of oncogenic driver pathways as a precision therapeutic strategy.Semantic proximity Read ↗

The hallmarks of oncogenic signaling: From pathways to resistance in cancer therapy.Semantic proximity Read ↗

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapySemantic proximity Read ↗

Paradoxical activation of oncogenic signaling as a cancer treatment strategySemantic proximity Read ↗

Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment StrategySemantic proximity Read ↗

Mechanism of activation and the rewired network: New drug design concepts.Semantic proximity Read ↗

Leveraging microenvironmental synthetic lethalities to treat cancerSemantic proximity Read ↗

Synthetic lethality-based targets for discovery of new cancer therapeutics.Semantic proximity Read ↗

Development of synthetic lethality in cancer: molecular and cellular classification.Semantic proximity Read ↗

Re-defining synthetic lethality by phenotypic profiling for precision oncology.Semantic proximity Read ↗

YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor CellsSemantic proximity Read ↗

Development of synthetic lethality anticancer therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.