Article

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted <i>in vivo</i> and <i>in vitro</i> Data

2024-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Drug-induced liver injury (DILI) has been significant challenge in drug discovery, often leading to clinical trial failures and necessitating drug withdrawals. The existing suite of in vitro proxy-DILI assays is generally effective at identifying compounds with hepatotoxicity. However, there is considerable interest in enhancing in silico prediction of DILI because it allows for the evaluation o...

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Literature Corpus work: 68ae1ae0-8672-55a7-bb89-8c54eebce2c0
DOI: 10.1101/2024.01.10.575128

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