Article

Assessing risks and mechanisms of idiosyncratic drug toxicity by fingerprints of cell signaling responses

2022-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Idiosyncratic drug-induced liver injury (DILI) is the leading cause of post-marketing drug withdrawal. Here, we describe a straightforward DILI liability assessment approach based on fingerprinting cell signaling responses. The readout is the activity of transcription factors (TF) that link signaling pathways to genes. Using a multiplex reporter assay for 45 TFs in hepatocytic cells, we assessed...

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Literature Corpus work: 38d05d6c-d3d1-5b07-910e-1a60083b2583
DOI: 10.1101/2022.12.01.518765

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