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Article

Comprehensive analysis of high-throughput transcriptomics to distinguish drug-induced liver injury (DILI) phenotypes.

Archives of toxicology - 1 Sept 2025

Shin Sangyeon, Lee Chanhee, Park Taesung

Abstract excerpt

Drug-Induced Liver Injury (DILI) is a major challenge in drug development, occurring due to liver damage caused by the adverse effects of drugs or xenobiotics. High-throughput transcriptomics (HTTr) provides mechanistic insights into drug-induced hepatotoxicity, complementing traditional chemical structure-based methods. To address the challenges posed by DILI, this study aimed to evaluate the suitability of HTTr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40464974
DOI: 10.1007/s00204-025-04089-x
PMCID: PMC12408718

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TG

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