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Article

A human liver organoid screening platform for DILI risk prediction

3 Feb 2023

Abstract excerpt

BACKGROUND & AIMS: Drug-induced liver injury (DILI), both intrinsic and idiosyncratic, causes frequent morbidity, mortality, clinical trial failures and post-approval withdrawal. This suggests an unmet need for improved in vitro models for DILI risk prediction that can account for diverse host genetics and other clinical factors. In this study, we evaluated the utility of human liver organoids (HLOs) for...

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Identifiers

PMID: 36738840
DOI: 10.1016/j.jhep.2023.01.019

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