Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support.

doi:10.1016/j.biopha.2024.116530

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Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 May 2024

Moreno-Torres Marta, López-Pascual Ernesto, Rapisarda Anna, Quintás Guillermo, Drees Annika, Steffensen Inger-Lise, Luechtefeld Thomas, Serrano-Candelas Eva, de Lomana Marina Garcia, Gadaleta Domenico, Dirven Hubert, Vinken Mathieu, Jover Ramiro

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BACKGROUND: Serum transaminases, alkaline phosphatase and bilirubin are common parameters used for DILI diagnosis, classification, and prognosis. However, the relevance of clinical examination, histopathology and drug chemical properties have not been fully investigated. As cholestasis is a frequent and complex DILI manifestation, our goal was to investigate the relevance of clinical features and drug properties...

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Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support.

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