Article

In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

2022-11-01

Abstract excerpt

Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed metabolism in patient-derived xenografts (tumorgrafts) from diverse forms of RCC. Tumorgrafts from VHL -mutant clear cell RCC (ccRCC) retained metabolic features of human ccRCC and engage in oxidative and reductive glutamine metabolism. We used several approaches to suppress glutamine m...

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Literature Corpus work: 68985a0c-2d05-5672-b9e9-81cad075bc8a
DOI: 10.1101/2022.10.31.514397

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