Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth

26 Feb 2019

Abstract excerpt

Despite a growing body of knowledge about the genomic landscape and molecular pathogenesis of sarcomas, translation of basic discoveries into targeted therapies and significant clinical gains has remained elusive. Renewed interest in altered metabolic properties of cancer cells has led to an exploration of targeting metabolic dependencies as a novel therapeutic strategy. In this study, we have characterized the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer Research and Treatments
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30808861
DOI: 10.1038/s41389-019-0129-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growthPMID 30808861Read ↗

The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibilitySemantic proximity Read ↗

Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.Semantic proximity Read ↗

Role and therapeutic targeting of glutamine metabolism in non‑small cell lung cancer (Review)Semantic proximity Read ↗

Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine PathwaysSemantic proximity Read ↗

Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.Semantic proximity Read ↗

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastomaSemantic proximity Read ↗

Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations.Semantic proximity Read ↗

Glioma cells require one-carbon metabolism to survive glutamine starvationSemantic proximity Read ↗

Glutamine addiction is a therapeutic target to block emergency myelopoiesisSemantic proximity Read ↗

Interplay between MycN and c-Myc regulates radioresistance and cancer stem cell phenotype in neuroblastoma upon glutamine deprivationSemantic proximity Read ↗

Metabolic Enzymes in Sarcomagenesis: Progress Toward Biology and Therapy.Semantic proximity Read ↗

Amino Acid and Glucose Fermentation Maintain ATP Content in Mouse and Human Malignant Glioma CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.