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Article

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism

11 May 2015

Abstract excerpt

The MYC oncogene is frequently mutated and overexpressed in human renal cell carcinoma (RCC). However, there have been no studies on the causative role of MYC or any other oncogene in the initiation or maintenance of kidney tumorigenesis. Here, we show through a conditional transgenic mouse model that the MYC oncogene, but not the RAS oncogene, initiates and maintains RCC. Desorption electrospray...

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Share to Cancer, Hypoxia, and Metabolism
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PMID: 25964345
DOI: 10.1073/pnas.1507228112

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