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Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines

15 Jan 2023

Abstract excerpt

Most tumor cells can use glutamine (Gln) for energy generation and biosynthetic purposes. Glutaminases (GAs) convert Gln into glutamate and ammonium. In humans, GAs are encoded by two genes: GLS and GLS2. In glioblastoma, GLS is commonly overexpressed and considered pro-oncogenic. We studied the metabolic effects of inhibiting GLS activity in T98G, LN229, and U87MG human glioblastoma cell lines by using the...

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PMID: 36672480
DOI: 10.3390/cancers15020531

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