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Article

Metabolic checkpoint CPS1 sustains TCA anaplerosis via urea cycle in IDH-mutant gliomas.

Cancer letters - 28 Aug 2026

Xu Hao, Zhang Licheng, Fu Minjie, Yang Hui, Wu Ruixin, Ma Jun, You Muyuan, Zhang Jinsen, Lv Kun, Wu Yonghe, Ye Dan, Hua Wei

Abstract excerpt

Isocitrate dehydrogenase-mutant (IDH-MUT) gliomas exhibit distinct metabolic profile marked by 2-hydroxyglutarate (2-HG) accumulation at the expense of α-ketoglutarate. How these tumors maintain the tricarboxylic acid (TCA) cycle, however, remained unclear. We conducted comprehensive metabolomic profiling using clinical cohorts, cell lines, and patient-derived organoids (PDOs). The metabolic dynamics of TCA and...

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Source

Identifiers

PMID: 42173273
DOI: 10.1016/j.canlet.2026.218606

Genes

CPS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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