Article

Computational Modeling of Chromatin Accessibility Identified Important Epigenomic Regulators

2021-09-07

Abstract excerpt

<title>Abstract</title> <p>Chromatin accessibility is essential for transcriptional activation of genomic regions. It is well established that transcription factors (TFs) and histone modifications (HMs) play critical roles in chromatin accessibility regulation. However, there is a lack of studies that quantify these relationships. Here we constructed a two-layer model to predict chromatin accessibility by integra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 688f865a-e880-5677-a216-f0cfca8e04ad
DOI: 10.21203/rs.3.rs-859635/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational Modeling of Chromatin Accessibility Identified Important Epigenomic RegulatorsDOI 10.21203/rs.3.rs-859635/v1Read

Comprehensive analysis of epigenetic signatures of human transcription control <sup>†</sup>Semantic proximity Read

Decoding transcriptional regulation via a human gene expression predictorSemantic proximity Read

Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancersSemantic proximity Read

DeepCAGE: Incorporating Transcription Factors in Genome-wide Prediction of Chromatin AccessibilitySemantic proximity Read

Computational prediction and characterization of cell-type-specific and shared binding sitesSemantic proximity Read

MethReg: estimating the regulatory potential of DNA methylation in gene transcriptionSemantic proximity Read

Inferring gene-regulatory networks using epigenomic priorsSemantic proximity Read

OpenAnnotate: a web server to annotate the chromatin accessibility of genomic regionsSemantic proximity Read

Benchmark and integration of resources for the estimation of human transcription factor activitiesSemantic proximity Read

Deep learning with implicit handling of tissue-specific phenomena predicts tumor DNA accessibility and immune activitySemantic proximity Read

Identification of mammalian transcription factors that bind to inaccessible chromatinSemantic proximity Read

Human transcriptional gene regulatory network compiled from 14 data resourcesSemantic proximity Read