Article

Inferring gene-regulatory networks using epigenomic priors

2024-04-25

Abstract excerpt

We show improved accuracy in-silico of inference of gene-regulatory network (GRN) structure, resulting from the use of an epigenomic prior network. We demonstrate important use-cases of our proposed methodology by re-analysing 12 datasets from 12 different studies. These include data from cells from human embryos, healthy adult tissue, and cancer, and include single-cell mRNA sequencing data, DNA methylation (DNAm...

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Literature Corpus work: 3092026b-3b94-5bd8-86e5-b2459f276b4c
DOI: 10.1101/2024.04.23.590858

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