Article

Macrophages Lacking TSC2 have mTORC1-dependent GPNMB Augmentation Ameliorating Cardiac Ischemia-Reperfusion Injury

2025-06-01

Abstract excerpt

<h4>Introduction</h4> Macrophages (MΦ) modulate both myocardial inflammatory and reparative phases following ischemia-reperfusion (I/R) injury. The mechanistic target of rapamycin (mTOR) is thought to play an important role in MΦ phenotype and functionality, but studies report conflicting net influences suggesting dependence on disease context and downstream signaling. Here, we tested the impact of MΦ with consti...

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Literature Corpus work: 687a8b8a-1379-5673-a587-67dd98964598
DOI: 10.1101/2025.05.29.656917

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