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Article

mTOR-dependent translation amplifies microglia priming in aging mice

27 Oct 2020

Abstract excerpt

Microglia maintain homeostasis in the brain. However, with age, they become primed and respond more strongly to inflammatory stimuli. We show here that microglia from aged mice had upregulated mTOR complex 1 signaling controlling translation, as well as protein levels of inflammatory mediators. Genetic ablation of mTOR signaling showed a dual yet contrasting effect on microglia priming: it caused an...

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PMID: 33108356
DOI: 10.1172/jci132727

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