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Article

Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching.

Acta pharmacologica Sinica - 1 May 2024

Shen Shi-Chun, Xu Jie, Cheng Cheng, Xiang Xin-Jian, Hong Bao-Yu, Zhang Meng, Gong Chen, Ma Li-Kun

Abstract excerpt

Following acute myocardial ischemia reperfusion (MIR), macrophages infiltrate damaged cardiac tissue and alter their polarization phenotype to respond to acute inflammation and chronic fibrotic remodeling. In this study we investigated the role of macrophages in post-ischemic myocardial fibrosis and explored therapeutic targets for myocardial fibrosis. Male mice were subjected to ligation of the left coronary...

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Source

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Identifiers

PMID: 38225394
DOI: 10.1038/s41401-023-01222-3
PMCID: PMC11053127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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