Article
mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.
PloS one - 1 Jan 2016
Taneike Manabu, Nishida Kazuhiko, Omiya Shigemiki, Zarrinpashneh Elham, Misaka Tomofumi, Kitazume-Taneike Rika, Austin Ruth, Takaoka Minoru, Yamaguchi Osamu, Gambello Michael J, Shah Ajay M, Otsu Kinya
Abstract excerpt
Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell growth, proliferation and metabolism. mTORC1 regulates protein synthesis positively and autophagy negatively. Autophagy is a major system to manage bulk degradation and recycling of cytoplasmic components and organelles. Tuberous sclerosis complex (TSC) 1 and 2 form a heterodimeric complex and inactivate Ras homolog enriched in brain,...
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