Article

CaBagE: a Cas9-based Background Elimination strategy for targeted, long-read DNA sequencing

2020-10-13

Abstract excerpt

A substantial fraction of the human genome is difficult to interrogate with short-read DNA sequencing technologies due to paralogy, complex haplotype structures, or tandem repeats. Long-read sequencing technologies, such as Oxford Nanopore’s MinION, enable direct measurement of complex loci without introducing many of the biases inherent to short-read methods, though they suffer from relatively lower throughput. T...

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Literature Corpus work: 6867611a-14a9-570e-948b-ef8ffc151f42
DOI: 10.1101/2020.10.13.337253

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