Article

Super elongation complex as a targetable dependency in diffuse midline glioma

2020-01-22

Abstract excerpt

Mutations in the histone 3 gene (H3K27M) are the eponymous drivers in diffuse intrinsic pontine gliomas (DIPGs) and other diffuse midline gliomas (DMGs), aggressive pediatric brain cancers for which no curative therapy currently exists. The salient molecular consequence of these recurrent oncohistones is a global loss of repressive H3K27me3 residues and broad epigenetic dysregulation. In order to identify specific...

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Literature Corpus work: 6861207d-674c-5fd0-a506-f8a95ca2051d
DOI: 10.1101/2020.01.22.913244

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