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Article

Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma

15 Jan 2021

Abstract excerpt

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is associated with transcriptional dysregulation driven by H3K27 mutation. The super elongation complex (SEC) is required for transcriptional elongation through release of RNA polymerase II (Pol II). Inhibition of transcription elongation by SEC disruption can be an effective therapeutic strategy of H3K27M-mutant DIPG. Here, we tested the effect of...

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PMID: 33471107
DOI: 10.1093/neuonc/noab009

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