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Evaluating apoptotic gene efficiency for CHO culture performance using targeted integration

2024-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Chinese hamster ovary (CHO) cells have long been the favoured platform for producing complex biopharmaceuticals such as monoclonal antibodies (mAbs). Cell death is a critical factor in all CHO cultures, dictating duration until harvest in batch cultures and viable cell density in perfusion. The programmed cell death, or apoptosis, pathway has been widely studied due to its relevance in affecting...

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Literature Corpus work
682ebb41-666d-5a75-8571-fbdd05ed20d3
DOI
10.1101/2024.05.29.596411
Open publication

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Evaluating apoptotic gene efficiency for CHO culture performance using targeted integrationDOI 10.1101/2024.05.29.596411
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