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Advances in recombinant antibody manufacturing

2 Mar 2016

Abstract excerpt

Since the first use of Chinese hamster ovary (CHO) cells for recombinant protein expression, production processes have steadily improved through numerous advances. In this review, we have highlighted several key milestones that have contributed to the success of CHO cells from the beginning of their use for monoclonal antibody (mAb) expression until today. The main factors influencing the yield of a production...

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PMID: 26936774
DOI: 10.1007/s00253-016-7388-9

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