Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting cell death pathways in fed‐batch bioreactors

1 Dec 2023

Abstract excerpt

Chinese hamster ovary (CHO) cells are widely used for production of biologics including therapeutic monoclonal antibodies. Cell death in CHO cells is a significant factor in biopharmaceutical production, impacting both product yield and quality. Apoptosis has previously been described as the major form of cell death occurring in CHO cells in bioreactors. However, these studies were undertaken when less was known...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Monoclonal and Polyclonal Antibodies Research
Share to Protein purification and stability
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38038229
DOI: 10.1002/biot.202300257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Dissecting cell death pathways in fed‐batch bioreactorsPMID 38038229Read ↗

Engineering death resistance in CHO cells for improved perfusion cultureSemantic proximity Read ↗

Evaluating apoptotic gene efficiency for CHO culture performance using targeted integrationSemantic proximity Read ↗

Cell death (apoptosis) in cell culture systemsSemantic proximity Read ↗

Label-Free Quantification of Apoptosis and Necrosis Using Stimulated Raman Scattering MicroscopySemantic proximity Read ↗

Comparison of Bcl-2 to a Bcl-2 deletion mutant for mammalian cells exposed to culture insults.Semantic proximity Read ↗

Specific inhibition of caspase-8 and -9 in CHO cells enhances cell viability in batch and fed-batch cultures.Semantic proximity Read ↗

The multiple mechanisms and modes of cell death after acetaminophen overdoseSemantic proximity Read ↗

Decoupling Growth and Protein Production in CHO Cells: A Targeted ApproachSemantic proximity Read ↗

Beyond viability: Advancing CHO cell culture process strategies to modulate host cell protein levelsSemantic proximity Read ↗

Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.