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A novel hydrogen peroxide evolved CHO host can improve the expression of difficult to express bispecific antibodies

6 Mar 2021

Abstract excerpt

The manufacture of bispecific antibodies by Chinese hamster ovary (CHO) cells is often hindered by lower product yields compared to monoclonal antibodies. Recently, reactive oxygen species have been shown to negatively impact antibody production. By contrast, strategies to boost cellular antioxidant capacity appear to be beneficial for recombinant protein expression. With this in mind, we generated a novel...

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PMID: 33675232
DOI: 10.1002/bit.27744

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