Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recombinase‐mediated cassette exchange ( <scp>RMCE</scp> ) for monoclonal antibody expression in the commercially relevant <scp>CHOK1SV</scp> cell line

24 Sept 2015

Abstract excerpt

To meet product quality and cost parameters for therapeutic monoclonal antibody (mAb) production, cell lines are required to have excellent growth, stability, and productivity characteristics. In particular, cell line generation stability is critical to the success of a program, especially where high cell line generation numbers are required for large in-market supply. However, a typical process for developing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral Infectious Diseases and Gene Expression in Insects
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26399954
DOI: 10.1002/btpr.2175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recombinase‐mediated cassette exchange ( <scp>RMCE</scp> ) for monoclonal antibody expression in the commercially relevant <scp>CHOK1SV</scp> cell linePMID 26399954Read ↗

The use of site-specific recombination and cassette exchange technologies for monoclonal antibody production in Chinese Hamster ovary cells: retrospective analysis and future directionsSemantic proximity Read ↗

Fast identification of reliable hosts for targeted cell line development from a limited‐genome screening using combined φC31 integrase and CRE‐Lox technologiesSemantic proximity Read ↗

Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase‐mediated cassette exchange systemSemantic proximity Read ↗

A high‐fidelity, dual site‐specific integration system in CHO cells by a Bxb1 recombinaseSemantic proximity Read ↗

Generation of monoclonal antibody-producing mammalian cell linesSemantic proximity Read ↗

Towards maximum acceleration of monoclonal antibody development: Leveraging transposase-mediated cell line generation to enable GMP manufacturing within 3 months using a stable poolSemantic proximity Read ↗

Recombinant antibody-producing stable CHOK1 pool stability studySemantic proximity Read ↗

Utilizing non-clonal CHO cell derived materials for preclinical studies of complex moleculesSemantic proximity Read ↗

Rapid high-throughput cloning and stable expression of antibodies in HEK293 cellsSemantic proximity Read ↗

Advances in recombinant antibody manufacturingSemantic proximity Read ↗

Evaluation of different vector design strategies for the expression of recombinant monoclonal antibody in CHO cellsSemantic proximity Read ↗

Recombinant protein expression by targeting pre-selected chromosomal lociSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.