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Article

Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells.

Journal of biotechnology - 15 Apr 2010

Becker Eric, Florin Lore, Pfizenmaier Klaus, Kaufmann Hitto

Abstract excerpt

Genetic engineering of producer cell lines for production of therapeutic antibodies in order to increase the yield of production processes remains a continuing challenge. Recently it was shown that heterologous expression of the active, spliced form of human X-box binding protein 1 (XBP-1(s)) can increase the amount of secreted protein products in mammalian cell culture processes. However, a prerequisite for the...

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Source

Identifiers

PMID: 19958799
DOI: 10.1016/j.jbiotec.2009.11.018

Genes

XIAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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