Article

Tet2 Controls β cells Responses to Inflammation in Type 1 Diabetes

2020-09-02

Abstract excerpt

β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). We identified a novel role of Tet2 in regulating immune killing of β cells. Tet2 is induced in murine and human β cells with inflammation but its expression is reduced in surviving β cells. Tet2-KO mice that receive WT bone marrow transplants develop insulitis but not diabetes and islet infiltrates do not eliminate β cells eve...

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Literature Corpus work: 68035f97-d22a-5307-b065-00edca8f5731
DOI: 10.1101/2020.09.01.278028

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