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Article

Genetic deficiency of Itgb2 or ItgaL prevents autoimmune diabetes through distinctly different mechanisms in NOD/LtJ mice.

Diabetes - 1 Jun 2009

Glawe John D, Patrick D Ross, Huang Meng, Sharp Christopher D, Barlow Shayne C, Kevil Christopher G

Abstract excerpt

OBJECTIVE: Insulitis is an important pathological feature of autoimmune diabetes; however, mechanisms governing the recruitment of diabetogenic T-cells into pancreatic islets are poorly understood. Here, we determined the importance of leukocyte integrins beta(2)(Itgb2) and alphaL (ItgaL) in developing insulitis and frank diabetes. RESEARCH DESIGN AND METHODS: Gene-targeted mutations of either Itgb2 or ItgaL were...

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Source

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Identifiers

PMID: 19223596
DOI: 10.2337/db08-0804
PMCID: PMC2682677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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